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Anti-Fos Antibody EPR883(2)


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA310495 Rabbit Monoclonal antibody against Fos 100ul $325 In Stock
LC401614 FOS HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Fos was used as an immunogen.
Clone NameEPR883(2) IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:10 - 1:100
Predicted MW Explanation 41 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for ICC/IF,IHC-P or IP.

Reference Data

Target NameHomo sapiens FBJ murine osteosarcoma viral oncogene homolog (FOS)
Alternative NameAP-1; C-FOS; p55
Database LinkNP_005243
Entrez Gene 2353 Human
Entrez Gene 14281 Mouse
Entrez Gene 314322 Rat
FunctionFos is nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, Fos and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. It has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (1). In some cases, expression of the FOS protein has also been associated with apoptotic cell death (2).
Related PathwayTranscription FactorsDruggable Genome MAPK signaling pathwayToll-like receptor signaling pathwayT cell receptor signaling pathwayB cell receptor signaling pathwayPathways in cancerColorectal cancerMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-c-Fos antibody [EPR883(2)]; All lanes : Anti-c-Fos antibody [EPR883(2)] at 1/1000 dilution.Lane 1 : Lysate of U937 cells treated with TPA.Lane 2 : U937 cell lysate.Lane 3 : Lysate of HeLa cells treated with TPA.Lane 4 : HeLa cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat ant-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 41 kDa.Observed band size : 62 kDa .


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