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Anti-FNTB Antibody EPR4707
Also for FNTB (NM_002028)
|A synthetic peptide corresponding to residues at the C-terminus of human FNTB was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:10000 - 1:50000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; FC: 1:100 - 1:500
|Does not react with Mouse, Rat. Is unsuitable for ICC.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for ICC.
|Homo sapiens farnesyltransferase, CAAX box, beta (FNTB)|
|The mammalian enzyme protein FNTB is a heterodimeric protein composing of two nonidentical subunits designated alpha and beta, which catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins (1,2). The beta subunit is responsible for peptide-binding (1). Chemical modification and site-directed mutagenesis studies have identified a conserved cysteine residue of protein farnesyltransferase, Cys299, in the beta subunit, as important for catalytic activity and zinc binding, suggesting that the thiolate of this residue may directly coordinate the zinc ion (3).|
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Western blot - FNTB antibody [EPR4707]; All lanes : Anti-FNTB antibody [EPR4707] at 1/10000 dilution.Lane 1 : JAR cell lysate.Lane 2 : A431 cell lysate.Lane 3 : U87-MG cell lysate.Lane 4 : A375 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled Goat anti-Rabbit at 1/2000 dilution.Predicted band size : 49 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FNTB antibody [EPR4707]; Immunohistochemical analysis of paraffin-embedded Human breast tissue using TA307491 at 1/100 dilution.