Home Antibody All anti-FNIP2 antibodies
Also for FNIP2 (NM_020840)
|FNIP2 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human FNIP2.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||ELISA, WB: 1 - 2 ug/ml, IHC: 5 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens folliculin interacting protein 2 (FNIP2)|
Entrez Gene 57600 Human
Entrez Gene 329679 Mouse
Entrez Gene 310538 Rat
|FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship. Multiple isoforms of FNIP2 are known to exist. This antibody is predicted to not cross-react with FNIP1.|
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Western blot analysis of FNIP2 in rat skeletal muscle lysate with FNIP2 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of FNIP2 in mouse skeletal muscle tissue with FNIP2 antibody at 5 ug/mL.