Home Antibody All anti-FMO3 antibodies
Anti-FMO3 Antibody EPR6967
Also for FMO3 (NM_001002294)
|A synthetic peptide corresponding to residues in human FMO3 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for IHC-P or IP.
|Homo sapiens flavin containing monooxygenase 3 (FMO3), transcript variant 2|
|dJ127D3.1; FMOII; TMAU|
Entrez Gene 2328 Human
Entrez Gene 14262 Mouse
Entrez Gene 84493 Rat
|Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO family is composed of 5 proteins. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of FMO3, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Mutations in FMO3 cause the disorder trimethylaminuria (TMAu), which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non-odorous trimethylamine N-oxide (1).|
|TransmembraneDruggable Genome Drug metabolism - cytochrome P450|
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Western blot - Anti-FMO3 antibody [EPR6967]; All lanes : Anti-FMO3 antibody [EPR6967] at 1/1000 dilution.Lane 1 : Rat kidney lysate.Lane 2 : Mouse liver lysate.Lane 3 : Rat liver lysate.Lane 4 : Human fetal liver lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 60 kDa.