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Home Antibody All anti-FMO3 antibodies

Anti-FMO3 Antibody EPR6967

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310493
  • Rabbit Monoclonal antibody against FMO3
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424145) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for FMO3 (NM_001002294)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human FMO3 was used as an immunogen.
Clone NameEPR6967 IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for IHC-P or IP.

Reference Data

Target NameHomo sapiens flavin containing monooxygenase 3 (FMO3), transcript variant 2
Alternative NamedJ127D3.1; FMOII; TMAU
Database LinkNP_001002294
FunctionFlavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO family is composed of 5 proteins. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of FMO3, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Mutations in FMO3 cause the disorder trimethylaminuria (TMAu), which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non-odorous trimethylamine N-oxide (1).
Related Pathway

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WB Image
Western blot - Anti-FMO3 antibody [EPR6967]; All lanes : Anti-FMO3 antibody [EPR6967] at 1/1000 dilution.Lane 1 : Rat kidney lysate.Lane 2 : Mouse liver lysate.Lane 3 : Rat liver lysate.Lane 4 : Human fetal liver lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 60 kDa.

 

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