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Anti-FLNA PHOSPHO Antibody EPR2308
Also for FLNA (NM_001456)
|A phospho specific peptide corresponding to residues surrounding serine 1083 of human Filamin A was used as an immunogen. This antibody only detects Filamin A phosphorylated at serine 1083.|
||Tissue culture supernatant
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; FC: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
|Does not react with Mouse, Rat. Is unsuitable for IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for IHC-P or IP.
|Homo sapiens filamin A, alpha (FLNA), transcript variant 1|
|ABP-280; ABPX; CSBS; CVD1; FLN; FLN-A; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD|
|Filamins are a family of high molecular mass cytoskeletal proteins that organize filamentous actin in networks and stress fibers. They anchor various transmembrane proteins to the actin cytoskeleton and provide a scaffold for a wide range of cytoplasmic signaling proteins (1). Actin-binding protein (Filamin A) is a ubiquitous dimeric actin cross-linking phosphoprotein of peripheral cytoplasm, where it promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins (2). The actin-binding domain is near the N-terminus of the subunit where the amino acid sequence is similar to other actin filament binding proteins, including alpha-actinin, beta-spectrin, dystrophin, and Dictyostelium abp-120. Detection of Filamin A / Fh1 proteins suggests that these presenilin-interacting proteins may be involved in the development of Alzheimer's disease, and interactions between presenilins and Filamin A /Fh1 may be functionally significant (3).|
MAPK signaling pathway
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Western blot - Filamin A (phospho S1083) antibody [EPR2308]; All lanes : Anti-Filamin A (phospho S1083) antibody [EPR2308] at 1/1000 dilution.Lane 1 : HeLa cell lysate, untreated.Lane 2 : HeLa cell lysate, treated with epidermal growth factor (EGF) .Lysates/proteins at 10 µg per lane.Predicted band size : 281 kDa.
Immunocytochemistry/ Immunofluorescence - Filamin A (phospho S1083) antibody [EPR2308]; Immunofluorescent staining of HeLa cells using TA307598 at a dilution of 1/100.