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Home Antibody All anti-FKBP5 antibodies

Anti-FKBP5 Antibody Hi51B

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326352
  • Mouse monoclonal FKBP51 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401331) , 20ug
100µg $325 3-7 Days
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WB(1)
IF(1)
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Also for FKBP5 (NM_004117)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenSynthetic peptide corresponding to the residues of human FKBP51
Clone NameHi51B IsotypeIgG
Species ReactivityCanine, Hamster, Human, Mouse, Rat, Rabbit Concentration1mg/mL
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:2000
BufferPBS, 50% glycerol
Purification Protein G Purified
Note Detects an ~51kDa protein representing FKBP51 in cell lysate. Also detects FKBP51 in whole tissue extracts from rat kidney and rat and mouse testes.

Reference Data

Target NameHomo sapiens FK506 binding protein 5 (FKBP5), transcript variant 1
Alternative NameAIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10
Database LinkNP_004108
FunctionHsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones . One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR cochaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins . FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex . The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90 . Although FKBP52 and FKBP51 share ~75% sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90-binding characteristics . FK506 binding protein 51 kDa (FKBP51 or otherwise referred to as FKBP54) has been identified as a progestininducible gene. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids .
Related Pathway

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WB Image
Western blot analysis of FKBP51 in HeLa cell lysates, using a 1:1000 dilution of the antibody
IF Image
IF localization of FKBP51 antibody in normal MK cells (shown in red). Courtesy of the Hospital Henri Mondor, France.

 

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