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Home Antibody All anti-FKBP4 antibodies

Anti-FKBP4 Antibody Hi52C

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA309334
  • Mouse Monoclonal anti-FKBP4 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC419585) , 20ug
100ug $325 3-7 Days
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IHC(1)
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Also for FKBP4 (NM_002014)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenSynthetic peptidecorresponding to the residuesof human FKBP52
Clone NameHi52C IsotypeIgG1
Species Reactivitydog, Hamster, Human, Mouse, Rat ConcentrationN/A
Guaranteed Application *IHC Suggested DilutionsWB, IP, IHC
BufferRabbit immunoglobulin in 50% glycerol

Reference Data

Target NameHomo sapiens FK506 binding protein 4, 59kDa (FKBP4)
Alternative NameFKBP51; FKBP52; FKBP59; HBI; Hsp56; p52; PPIase
Database LinkNP_002005
FunctionThe protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq].
Related Pathway

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IHC Image
Prostate tissue was histologically stained with antibodies specific for FKBP52. The strongest staining for FKBP52 is in ductal epithelial cells.

 

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