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Home Antibody All anti-FKBP1A antibodies

Anti-FKBP1A Antibody EP3887

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307668
  • Rabbit monoclonal antibody against FKBP12(clone EP3887)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400279) , 20ug
100ul $325 3-7 Days
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WB(1)
IF(1)
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Also for FKBP1A (NM_000801)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human FKBP12 was used as an immunogen.
Clone NameEP3887 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:1000 - 1:10000; ICC/IF: 1:50 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens FK506 binding protein 1A, 12kDa (FKBP1A), transcript variant 1
Alternative NameFKBP-12; FKBP-1A; FKBP1; FKBP12; PKC12; PKCI2; PPIASE
Database LinkNP_000792
FunctionFKBP12 (Fkbp1a) is a member of the FK-506-binding protein (FKBP) family. This family of proteins possesses peptidyl-prolyl cis-trans isomerase (PPIase) activity and is believed to play an important role in accelerating the rate at which proteins fold into their native conformations (1). FKBP12 was originally identified as a cytosolic receptor for the immunosuppressant drugs, FK506 and rapamycin, and later shown to be involved in cell-cycle regulation and in intracellular calcium homeostasis. Binding of FKBP12 to rapamycin through its FK506/rapamycin-binding/ PPIase domain mediates the immunosuppressive and anti-tumor effects of rapamycin, a drug that has been shown to arrest tumor cells in G1 phase of the cell cycle and to reduce tumor angiogenesis (2). FKBP12 is highly conserved from yeast through human and is relatively abundant in most tissues and cell types (3).
Related Pathway
TGF Beta Signaling Pathway

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WB Image
Western blot - FKBP12 antibody [EP3887]; All lanes : Anti-FKBP12 antibody [EP3887] at 1/1000 dilution.Lane 1 : Fetal brain lysate.Lane 2 : HL-60 brain lysate.Lane 3 : U937 lysate.Lane 4 : SH-SY5Y lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 12 kDa.
IF Image
Immunocytochemistry/ Immunofluorescence - FKBP12 antibody [EP3887]; Immunofluorescent staining of FKBP12 in HeLa cells using TA307668 at 1/50 dilution.

 

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