Home Antibody All anti-FKBP1A antibodies
Anti-FKBP1A Antibody EP3887
Also for FKBP1A (NM_000801)
|A synthetic peptide corresponding to residues in human FKBP12 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; ICC/IF: 1:50 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens FK506 binding protein 1A, 12kDa (FKBP1A), transcript variant 1|
|FKBP-12; FKBP-1A; FKBP1; FKBP12; PKC12; PKCI2; PPIASE|
Entrez Gene 2280 Human
Entrez Gene 14225 Mouse
Entrez Gene 25639 Rat
|FKBP12 (Fkbp1a) is a member of the FK-506-binding protein (FKBP) family. This family of proteins possesses peptidyl-prolyl cis-trans isomerase (PPIase) activity and is believed to play an important role in accelerating the rate at which proteins fold into their native conformations (1). FKBP12 was originally identified as a cytosolic receptor for the immunosuppressant drugs, FK506 and rapamycin, and later shown to be involved in cell-cycle regulation and in intracellular calcium homeostasis. Binding of FKBP12 to rapamycin through its FK506/rapamycin-binding/ PPIase domain mediates the immunosuppressive and anti-tumor effects of rapamycin, a drug that has been shown to arrest tumor cells in G1 phase of the cell cycle and to reduce tumor angiogenesis (2). FKBP12 is highly conserved from yeast through human and is relatively abundant in most tissues and cell types (3).|
|Druggable Genome |
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Western blot - FKBP12 antibody [EP3887]; All lanes : Anti-FKBP12 antibody [EP3887] at 1/1000 dilution.Lane 1 : Fetal brain lysate.Lane 2 : HL-60 brain lysate.Lane 3 : U937 lysate.Lane 4 : SH-SY5Y lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 12 kDa.
Immunocytochemistry/ Immunofluorescence - FKBP12 antibody [EP3887]; Immunofluorescent staining of FKBP12 in HeLa cells using TA307668 at 1/50 dilution.