FHL1 is a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode, and these proteins are involved in many cellular processes. Mutations in FHL1 have been found in patients with Emery-Dreifuss muscular dystrophy (1).
Delta-Notch Signaling Pathway
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