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Anti-FGG Antibody EPR3084


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307696 Rabbit monoclonal antibody against Fibrinogen gamma chain (clone EPR3084 ) 100ul $325 In Stock
LC400173 FGG HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Fibrinogen gamma chain was used as an immunogen.
Clone NameEPR3084 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsIHC: 1:100 - 250, WB: 1:500 - 1,000,
Predicted MW Explanation 52 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens fibrinogen gamma chain (FGG), transcript variant gamma
Alternative Namefibrinogen, gamma chain; fibrinogen, gamma polypeptide; fibrinogen gamma chain
Database LinkNP_000500
Entrez Gene 2266 Human
FunctionFibrinogen is comprised of two sets of three polypeptide chains termed alpha, beta and gamma that are joined by disulfide bridging within the N-terminal E domain (1). Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. Fibrinogen binds through its gamma chain to cell surface receptors, growth factors, and coagulation factors to perform key roles in fibrin clot formation, platelet aggregation, and wound healing (2). Fibrinogen gamma chain, a fibrinogen gamma-chain variant generated via alternative mRNA processing, binding to thrombin and factor VIII results in clots that are mechanically stiffer and resistant to fibrinolysis (2). Elevated plasma fibrinogen gamma concentration is associated with myocardial infarction (3). Fibrinogen-gamma C-terminal fragments can induce endothelial barrier dysfunction and microvascular leak (4).
Related PathwaySecreted ProteinTransmembraneDruggable Genome Complement and coagulation cascades

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Fibrinogen gamma chain antibody [EPR3084]; Anti-Fibrinogen gamma chain antibody [EPR3084] at 1/500 dilution + Human plasma lysate at 10 ug.Secondary.HRP labelled goat anti-rabbit IgG at 1/2000 dilution.Predicted band size : 52 kDa.

IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Fibrinogen gamma chain antibody [EPR3084]; TA307696, at a 1/100 dilution, staining Fibrinogen gamma chain in paraffin embedded Human liver tissue by Immunohistochemistry.


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