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Home Antibody All anti-FGG antibodies

Anti-FGG Antibody EPR3085

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307695
  • Rabbit monoclonal antibody against Fibrinogen gamma chain(clone EPR3085)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400173) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for FGG (NM_000509)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Fibrinogen gamma chain was used as an immunogen.
Clone NameEPR3085 IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:10 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for ICC/IF,IHC-P or IP.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for ICC/IF,IHC-P or IP.

Reference Data

Target NameHomo sapiens fibrinogen gamma chain (FGG), transcript variant gamma-A
Alternative Namefibrinogen, gamma chain; fibrinogen, gamma polypeptide; fibrinogen gamma chain
Database LinkNP_000500
FunctionFibrinogen is comprised of two sets of three polypeptide chains termed alpha, beta and gamma that are joined by disulfide bridging within the N-terminal E domain (1). Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. Fibrinogen binds through its gamma chain to cell surface receptors, growth factors, and coagulation factors to perform key roles in fibrin clot formation, platelet aggregation, and wound healing (2). Fibrinogen gamma chain, a fibrinogen gamma-chain variant generated via alternative mRNA processing, binding to thrombin and factor VIII results in clots that are mechanically stiffer and resistant to fibrinolysis (2). Elevated plasma fibrinogen gamma concentration is associated with myocardial infarction (3). Fibrinogen-gamma C-terminal fragments can induce endothelial barrier dysfunction and microvascular leak (4).
Related Pathway
Hemostasis

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WB Image
Western blot - Anti-Fibrinogen gamma chain antibody [EPR3085]; Anti-Fibrinogen gamma chain antibody [EPR3085] at 1/1000 dilution + Human plasma cell lysate at 10 µg.Secondary.Goat Anti-rabbit HRP at 1/2000 dilution.Predicted band size : 52 kDa.

 

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