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Anti-FGG Antibody EPR3085
|A synthetic peptide corresponding to residues in human Fibrinogen gamma chain was used as an immunogen.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; FC: 1:10 - 1:100
|Does not react with Mouse, Rat. Is unsuitable for ICC/IF,IHC-P or IP.|
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Is unsuitable for ICC/IF,IHC-P or IP.
|Homo sapiens fibrinogen gamma chain (FGG), transcript variant gamma-A|
|fibrinogen, gamma chain; fibrinogen, gamma polypeptide; fibrinogen gamma chain|
Entrez Gene 2266 Human
|Fibrinogen is comprised of two sets of three polypeptide chains termed alpha, beta and gamma that are joined by disulfide bridging within the N-terminal E domain (1). Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. Fibrinogen binds through its gamma chain to cell surface receptors, growth factors, and coagulation factors to perform key roles in fibrin clot formation, platelet aggregation, and wound healing (2). Fibrinogen gamma chain, a fibrinogen gamma-chain variant generated via alternative mRNA processing, binding to thrombin and factor VIII results in clots that are mechanically stiffer and resistant to fibrinolysis (2). Elevated plasma fibrinogen gamma concentration is associated with myocardial infarction (3). Fibrinogen-gamma C-terminal fragments can induce endothelial barrier dysfunction and microvascular leak (4).|
|Secreted ProteinTransmembraneDruggable Genome Complement and coagulation cascades|
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Western blot - Anti-Fibrinogen gamma chain antibody [EPR3085]; Anti-Fibrinogen gamma chain antibody [EPR3085] at 1/1000 dilution + Human plasma cell lysate at 10 ug.Secondary.Goat Anti-rabbit HRP at 1/2000 dilution.Predicted band size : 52 kDa.