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Also for FGFR4 (NM_002011)
|Purified recombinant FGFR4 fusion protein was used to produced this monoclonal antibody.|
||WB: 1:2000; ELISA: 1: 1,000;
|Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.|
|Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
|Homo sapiens fibroblast growth factor receptor 4 (FGFR4), transcript variant 1|
|CD334; JTK2; TKF|
|FGFR4 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.|
MAPK signaling pathway
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(LEFT)Western blot analysis of anti-FGFR4 Monoclonal Antibody by FGFR4 recombinant protein(Fragment 42KD). FGFR4 protein (arrow) was detected using the purified Mab. (RIGHT)Western blot analysis of FGFR4 (arrow) using mouse monoclonal FGFR4 antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FGFR4 gene (Lane 2) (Origene Technologies)