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Home Antibody All anti-FGFR4 antibodies

Anti-FGFR4 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA302088 UnMouse Monoclonal Antibody against FGFR4 (Ascites) 100ul $325 In Stock
LC400735 FGFR4 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(2)
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Also for FGFR4 (NM_002011)
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OriGene Data

ImmunogenPurified recombinant FGFR4 fusion protein was used to produced this monoclonal antibody.
Clone Name IsotypeIgG1 Kappa
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:2000
Predicted MW Explanation 87954 Da
BufferMouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Reference Data

Target NameHomo sapiens fibroblast growth factor receptor 4 (FGFR4), transcript variant 1
Alternative NameCD334; JTK2; TKF
Database LinkNP_002002
Entrez Gene 2264 Human
FunctionFGFR4 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
Related PathwayProtein KinaseDruggable Genome MAPK signaling pathwayEndocytosisRegulation of actin cytoskeleton

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of anti-FGFR4 Monoclonal Antibody (Cat.#TA302088) by FGFR4 recombinant protein(Fragment 42KD). FGFR4 protein (arrow) was detected using the ascites Mab.
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Western blot analysis of FGFR4 (arrow) using mouse monoclonal FGFR4 antibody(Ascites) (Cat.#TA302088). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FGFR4 gene (Lane 2) (Origene Technologies) (1:2000)
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