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Home Antibody All anti-FGFR1 antibodies

Anti-FGFR1 Antibody EPR806Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301021
  • Rabbit Monoclonal Antibody against FGFR1 (Clone EPR806Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402963) , 20ug Explanation
100ul 325 In Stock
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WB(1)
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Also for FGFR1 (NM_023110)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human FGFR1 was used as an immunogen.
Clone NameEPR806Y IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 1
Alternative NamebFGF-R-1; BFGFR; CD331; CEK; FGFBR; FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM; OGD
Database LinkNP_075598
Entrez Gene 2260 Human
FunctionFibroblast growth factors (FGFs) are polypeptide mitogens that induce the proliferation of a wide variety of cell types (1). Fibroblast growth factor (FGF)/FGF receptor (FGFR1) signaling plays a crucial role in mesoderm formation and patterning. Studies suggest that FGFR1, among the different FGFRs, may play a role in cardiogenesis. Data point to a nonredundant role for FGFR1-mediated signaling in cardiomyocyte development (2). It has also been shown that during development, FGFR1 is required for the generation of the precursor pool, which gives rise to the auditory sensory epithelium. Data also suggest that FGFR1 might have a distinct later role in intercellular signaling within the differentiating auditory sensory epithelium (3). Highly conserved FGF-D2 and FGF-linker (between D2-D3) interfaces define a general binding site for all FGF-FGFR complexes. Specificity is achieved through interactions between the N-terminal and central regions of FGFs and two loop regions in D3 that are subject to alternative splicing. These structures provide a molecular basis for FGF1 as a universal FGFR ligand and for modulation of FGF-FGFR specificity through primary sequence variations and alternative splicing (4).
Related PathwayProtein KinaseTransmembraneDruggable Genome MAPK signaling pathwayAdherens junctionRegulation of actin cytoskeletonPathways in cancerProstate cancerMelanomaMore Pathways >>

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WB Image
Western blot - FGFR1 antibody [EPR806Y]; Anti-FGFR1 antibody [EPR806Y] at 1/500 dilution + SH-SY-5Y cell lysate at 10 ug.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 92 kDa.Observed band size : 130 kDa .

 

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