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Home Antibody All anti-FGD4 antibodies

Anti-FGD4 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA309049 Rabbit polyclonal antibody to FGD4 (FYVE, RhoGEF and PH domain containing 4) 100ul $325 3-7 Days
LC403384 FGD4 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)
IF(1)

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 49 and 327 of FGD4 (Uniprot ID#Q96M96)
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 87kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.

Reference Data

Target NameHomo sapiens FYVE, RhoGEF and PH domain containing 4 (FGD4), transcript variant 3
Alternative NameCMT4H; FRABP; ZFYVE6
Database LinkNP_640334
Entrez Gene 121512 Human
FunctionThis gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. [provided by RefSeq]
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Sample (30 ug of whole cell lysate). A: Molt-4 . 7.5% SDS PAGE. TA309049 diluted at 1:1000
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Immunohistochemical analysis of paraffin-embedded SG xenograft, using FGD4(TA309049) antibody at 1:100 dilution.
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Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using FGD4(TA309049) antibody at 1:200 dilution.
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