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Anti-FGA Antibody EPR2919

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307697
  • Rabbit monoclonal antibody against Fibrinogen alpha chain (clone EPR2919 )
100ul 325 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Fibrinogen (alpha chain) was used as an immunogen.
Clone NameEPR2919 IsotypeIgG
Species ReactivityHuman, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsICC: 1:50 - 100, IHC: 1:50 - 100, IP: 1:50, WB: 1:2,000 - 10,000,
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse

Reference Data

Target NameHomo sapiens fibrinogen alpha chain (FGA), transcript variant alpha-E
Alternative NameFib2
Database LinkNP_000499
FunctionFibrinogen is a plasma glycoprotein synthesized primarily in the liver (1). It is comprised of two identical molecular halves, each consisting of three non-identical subunit polypeptides designated as A alpha, B beta- and gamma-chains held together by multiple disulfide bonds (2). Fibrinogen acts as the main factor in the formation of a blood clot by polymerization to a fibrin network and by enabling platelets to aggregate (3). The conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Defects in fibrinogen are a cause of congenital afibrinogenemia, a rare autosomal recessive disorder, and amyloidosis type 8, also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis (4).
Related Pathway
Hemostasis

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WB Image
Western blot - Fibrinopeptide A antibody [EPR2919]; All lanes : Anti-Fibrinopeptide A antibody [EPR2919] at 1/2000 dilution.Lane 1 : Human plasma lysate.Lane 2 : Fetal liver lysate.Lane 3 : HepG2 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 95 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Fibrinopeptide A antibody [EPR2919]; Immunohistochemical analysis of paraffin-embedded human hepatocellular carcinoma using TA307697 at 1/2000 dilution.

 

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