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Anti-FGA Antibody EPR2919
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|A synthetic peptide corresponding to residues in human Fibrinogen (alpha chain) was used as an immunogen.|
||ICC: 1:50 - 100, IHC: 1:50 - 100, IP: 1:50, WB: 1:2,000 - 10,000,
|Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens fibrinogen alpha chain (FGA), transcript variant alpha-E|
|Fibrinogen is a plasma glycoprotein synthesized primarily in the liver (1). It is comprised of two identical molecular halves, each consisting of three non-identical subunit polypeptides designated as A alpha, B beta- and gamma-chains held together by multiple disulfide bonds (2). Fibrinogen acts as the main factor in the formation of a blood clot by polymerization to a fibrin network and by enabling platelets to aggregate (3). The conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Defects in fibrinogen are a cause of congenital afibrinogenemia, a rare autosomal recessive disorder, and amyloidosis type 8, also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis (4). |
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Western blot analysis on (A) human plasma, (B) fetal liver and (C) HepG2 cell lysates using anti-Fibrinogen alpha chain RabMAb .
Immunohistochemical analysis of paraffin-embedded human hepatocellular carcinoma using anti-Fibrinogen alpha chain RabMAb .