Home Antibody All anti-FERMT3 antibodies
Also for FERMT3 (NM_031471)
|KINDLIN3 antibody was raised against a 19 amino acid peptide near the carboxy terminus of the human KINDLIN3.|
|Human, Mouse, Rat
||WB: 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens fermitin family member 3 (FERMT3), transcript variant URP2SF|
|KIND3; MIG-2; MIG2B; UNC112C; URP2; URP2SF|
|The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.|
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Western blot analysis of KINDLIN3 in rat spleen lysate with KINDLIN3 antibody at (A) 1 and (B) 2 µg/ml.