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Home Antibody All anti-FERMT3 antibodies

Anti-FERMT3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306643
  • Rabbit Polyclonal KINDLIN3 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403121) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
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Also for FERMT3 (NM_031471)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenKINDLIN3 antibody was raised against a 19 amino acid peptide near the carboxy terminus of the human KINDLIN3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens fermitin family member 3 (FERMT3), transcript variant URP2SF
Alternative NameKIND3; MIG-2; MIG2B; UNC112C; URP2; URP2SF
Database LinkNP_113659
Entrez Gene 83706 Human
Entrez Gene 108101 Mouse
Entrez Gene 309186 Rat
FunctionThe three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of KINDLIN3 in rat spleen lysate with KINDLIN3 antibody at (A) 1 and (B) 2 µg/ml.

 

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