Home Antibody All anti-FEM1B antibodies
Also for FEM1B (NM_015322)
|F1A alpha antibody was raised against a peptide corresponding to amino acids 609 to 622 of human F1A alpha. This sequence is identical to the corresponding sequence of mouse FEM1b .|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens fem-1 homolog b (C. elegans) (FEM1B)|
|F1A-ALPHA; F1AA; FEM1-beta|
Entrez Gene 10116 Human
Entrez Gene 14155 Mouse
Entrez Gene 315745 Rat
|Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aalpha and FEM1b (1,2). F1Aalpha/FEM1beta is the homologue of C. elegans sex determining protein FEM-1 (1,2). FEM-1/F1Aalpha is cleaved by CED-3 and caspase (3). FEM-1/F1Aalpha associates with CED-4 and its mammalian homologue Apaf-1 (3). Overexpression of F1Aalpha induces apoptosis. F1Aalpha is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aalpha is expressed in a variety of human and mouse tissues (1,2)|
|Druggable Genome |
* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
Western blot analysis of F1A alpha in mouse (A) and rat (B) liver tissue lysates with F1A alpha antibody at 1 ug/ml.
Immunohistochemistry of F1Aa in mouse liver tissue with F1Aa antibody at 5 ug/ml.