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Anti-FCGR2B Antibody EP888Y
Also for FCGR2B (NM_001002275)
|A synthetic peptide corresponding to residues at the C-terminus of human Fc-gamma RII-b was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:50000; IHC-P: Use at an assay dependent dilution; FC: 1:20; IP: 1:50
|40-44 kDa (3 isoforms)
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2B), transcript variant 4|
|CD32; CD32B; FCG2; FCGR2; IGFR2|
Entrez Gene 2213 Human
|Low affinity IgG Fc receptor gamma II (Fc-gamma II), also known as CD32, is a member of the immunoreceptor tyrosine-based activating/inhibitory motif (ITAM/ITIM) family. Fc gamma receptors play a critical role in immunity by linking the IgG antibody mediated response with the regulatory functions of the immune system (1). Three classes of Fc gamma receptor exist; Fc gamma RI (CD64, a high affinity receptor), Fc gamma RII, and RIII (CD32 and CD16 respectively, both low affinity receptors). Fc gamma RIIa is an activating receptor, while RIIb1, RIIb2, and RIIb3 are inhibitory receptors generated by alternative splicing (1-2). Fc gamma RIIa is critical for antigen-presenting-cell activation and Fc gamma RIIb downregulates B-cell functions (3). Fc gamma RIIb has also been known to block the inflammatory immune response in mice (4). Once phosphorylated on tyrosine residues, Fc gamma RIIb associates with SHIP to downregulate phagocytosis. |
|ES Cell Differentiation/IPSTransmembrane B cell receptor signaling pathwayFc gamma R-mediated phagocytosisSystemic lupus erythematosus|
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Western blot - CD32 antibody [EP888Y]; Anti-CD32 antibody [EP888Y] at 1/50000 dilution + 10 ug Daudi cell lysate .Secondary.Goat anti rabbit HRP 1/2000.Observed band size : 49-55 kDa .
Immunohistochemistry (Paraffin-embedded sections) - CD32 antibody [EP888Y]; Ab45143 staining human CD32 (1/100) in human lymph node by immunohistochemistry using paraffin embedded tissue.