CD23 is a type II transmembrane glycoprotein which functions as a receptor for IgE. CD23 is involved in the regulation of IgE production and in the differentiation of B-cells. It is expressed in many haemopoietic cell types CD21 has been identified as a ligand for CD23 in the control of IgE production (1). CD23 expression has been detected in neoplastic cells from B cell chronic lymphocyctic leukaemia and in some centroblastic/centrocytic lymphoma cases. CD23 staining is used in the differentiation of small lymphocytic lymphomas and mantle cell lymphoma (2).
Hematopoietic cell lineage
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