Home Antibody All anti-FBXW2 antibodies
Also for FBXW2 (NM_012164)
| Peptide with sequence C-KRGSSFLAGEHPG, from the C Terminus of the protein sequence according to NP_036296.1.|
|Test: Human, Mouse, Rat. Expected from seq similarity: Human, Mouse, Rat, Dog, Pig, Cow
||ELISA: 1:128,000. WB: 0.3-1.5µg/ml. IHC: 2-3µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
| Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
|Homo sapiens F-box and WD repeat domain containing 2 (FBXW2)|
|FBW2; Fwd2; Md6|
Entrez Gene 26190 Human
Entrez Gene 30050 Mouse
Entrez Gene 311881 Rat
Entrez Gene 610990 Dog
|F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq]. COMPLETENESS: complete on the 3' end. |
|Druggable Genome |
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TA302888 staining (0.3µg/ml) of Human Kidney lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
TA302888 (3µg/ml) staining of paraffin embedded Human Kidney. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining.