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Home Antibody All anti-FBXW11 antibodies

Anti-FBXW11 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA319474 Rabbit polyclonal Beta TrCP2 antibody 100ug $325 3-7 Days
LC415862 FBXW11 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)

OriGene Data

ImmunogenThis affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the N-terminal of human ßTrCP2 protein.
Clone Name IsotypeIgG
Species Reactivityhuman, mouse, dog, chicken, bovine, monkey Concentration1.0 mg/mL
Guaranteed Application *WB Suggested DilutionsELISA: 1:10,000 – 1:100,000, WB: 1:200 to 1:1,000, IF: User Optimized
Buffer0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Note This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.

Reference Data

Target NameHomo sapiens F-box and WD repeat domain containing 11 (FBXW11), transcript variant 3
Alternative NameBTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos
Database LinkNP_036432
Entrez Gene 23291 Human
Entrez Gene 103583 Mouse
Entrez Gene 708990 Monkey
Entrez Gene 479291 Dog
Function
Related PathwayDruggable Genome Oocyte meiosisUbiquitin mediated proteolysisWnt signaling pathwayHedgehog signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB using Anti-ßTrCP2 antibody shows detection of mouse and human ßTrCP2 (arrowhead) in NIH3T3 (lane 1) and 293 (lane 2) whole cell lysates.The primary antibody was used at1:200.  Detection occurred using HRP conjugated Goat-anti-Rabbit IgG diluted 1:20,000 in blocking buffer (p/n MB-070) for 1 h at 4 ?.
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