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Anti-FAS TRUEMAB Antibody Clone OTI2C2

TrueMAB™ Antibodies - Made against Authentic Protein Antigens


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA506937 FAS mouse monoclonal antibody, clone OTI2C2 (formerly 2C2) 100ul 325
In Stock
LC424961 FAS HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF506937 Carrier-free (BSA/glycerol-free) FAS mouse monoclonal antibody, clone OTI2C2 (formerly 2C2) 100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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OriGene Data

ImmunogenFull length human recombinant protein of human FAS(NP_000034) produced in HEK293T cell.
Clone NameClone OTI2C2 IsotypeIgG1
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB Suggested Dilutions WB 1:2000,
Predicted MW Explanation 36 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens Fas cell surface death receptor (FAS), transcript variant 1
Alternative NameALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6
Database LinkNP_000034
Entrez Gene 355 Human
FunctionThe protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011].
Related PathwaySecreted ProteinES Cell Differentiation/IPSDruggable Genome MAPK signaling pathwayCytokine-cytokine receptor interactionp53 signaling pathwayApoptosisNatural killer cell mediated cytotoxicityType I diabetes mellitusMore Pathways >>

* Availability is in business days
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FAS (RC204520, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FAS.


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