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Home Antibody All anti-FAS antibodies

Anti-FAS TRUEMAB Antibody Clone 2C2

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA506937
  • FAS mouse monoclonal antibody,clone 2C2
  • FREE positive control: HEK293T cell transient overexpression lysate (LC424961) , 20ug
100ul 325 In Stock
CF506937
  • Carrier-free (BSA/glycerol-free) FAS mouse monoclonal antibody,clone 2C2
100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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WB(1)
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Also for FAS (NM_000043)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human FAS(NP_000034) produced in HEK293T cell.
Clone NameClone 2C2 IsotypeIgG1
Species ReactivityHuman Concentration1.00mg/ml
Guaranteed Application *WB Suggested Dilutions WB 1:2000,
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens Fas cell surface death receptor (FAS), transcript variant 1
Alternative NameALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6
Database LinkNP_000034
FunctionThe protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011].
Related Pathway
Adipogenesis
Apoptosis
Cytokine-cytokine receptor interaction
MAPK signaling pathway

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WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FAS (RC204520, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FAS.

 

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