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Anti-FAS Antibody EOS9.1
||0.5-1mg/ml (lot dependent)
||Flow, Functional Assay
|Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Affinity purified (Protein A or G Sepharose)
|Homo sapiens Fas cell surface death receptor (FAS), transcript variant 1|
|ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6|
|The EOS9.1 monoclonal antibody reacts with human CD95 (Fas, Apo-1), a 40-50 kDa member of the TNFR superfamily. CD95 is expressed by a broad range of hematopoietic and non-hematopoietic cells including monocytes, neutrophils, activated lymphocytes and fibroblasts. Interaction of CD95 on mature lymphocytes with its ligand (FasL) induces apoptosis and is thought to be important in peripheral tolerance. EOS9.1 does not block binding of DX2, another antibody specific for human CD95.|
Cytokine-cytokine receptor interaction
MAPK signaling pathway
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The Jurkat cell line was treated for 6 hours with medium alone (left) or 0.1 ug/mL of Anti-Human CD95 (APO-1/Fas) Functional Grade Purified (right). Induction of apoptosis in these cells was determined by staining with Propidium Iodide and Anti-BrdU-FITC using the Apo-BrdU Apoptosis Detection Kit .