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Home Antibody All anti-FAP antibodies

Anti-FAP Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319451
  • Rabbit polyclonal Fibroblast Activation Protein antibody
100ug 325 In Stock
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WB(1)

OriGene Data

ImmunogenThis affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of mouse FAP protein.
Clone Name IsotypeIgG
Species Reactivitymouse Concentration1.1mg/ml
Guaranteed Application *WB Suggested DilutionsELISA: 1:100,000, WB: 1:500 to 1:2,000
Buffer0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Note This antibody is suitable for Cancer, Immunology and Nuclear Signaling research. Fibroblast Activation Protein (FAP)  is expressed in the stroma of sites that are undergoing wound healing. In addition, it has recently been reported that FAP is expressed in the stroma of sites of metastatic disease. Inhibition of FAP may lead to a dramatic decrease in the number of metastatic osteosarcoma lung nodules.  FAP exists as an inactive monomer and when activated forms homodimers or heterodimers with DPP4.  Multiple isoforms of FAP are reported as alternative splicing products from a common gene.

Reference Data

Target NameMus musculus fibroblast activation protein (Fap)
Alternative Name
Database LinkNP_032012
Entrez Gene 14089 Mouse
Function
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot using affinity purified anti-FAP antibody shows detection of FAP protein in whole cell lysates from FAP expressing HEK cells (lane 4) but not control HEK cells (lane 3).  Specific band staining is blocked when the primary antibody is pre-incubated with immunizing peptide (lanes 1 and 2 respectively).  The band at ~90 kDa, indicated by the arrowhead, corresponds to the expected molecular weight of transfected FAP. Primary antibody was used at 1:1,000.  Personal communication, S.Kim, NCI, Bethesda, MD.

 

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