Home Antibody All anti-FAM59A antibodies
Also for FAM59A (NM_022751)
|FAM59A antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human FAM59A.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens GRB2 associated, regulator of MAPK1 (GAREM), transcript variant 2|
|C18orf11; FAM59A; Gm944|
|FAM59A, also known as GAREM, was initially identified through a mass spectroscoptic method that measures different phosphotyrosine states of proteins in response to different cell stimuli. FAM59A is a downstream molecule in the EGF signaling pathway that is tyrosine-phosphorylated, and this phosphorylation is needed for the binding of Grb2, an adaptor protein crucial to the transduction of growth signals from the plasma membrane to the nucleus. ERK activation in response to EGF stimulation is regulated by FAM59A in COS-7 and HeLa cells, and the overexpression of FAM59A stimulated cell proliferation and colony formation in soft agar, suggesting that FAM59A might be a critical protein with roles in ligand-mediated signaling pathway of the EGF receptor and the tumorigenesis of cells.|
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Western blot analysis of FAM59A in rat liver tissue lysate with FAM59A antibody at (A) 1 and (B) 2 µg/ml.
Immunohistochemistry of PLEKHM3 in human brain tissue with PLEKHM3 antibody at 5 ug/ml.