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Anti-FAM193B Antibody Polyclonal
Also for FAM193B (NM_019057)
|FAM193B antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human FAM193B.|
||WB: 1 ug/ml, IF: 20 ug/ml
|FAM193B Antibody is supplied in PBS containing 0.02% sodium azide.|
|FAM193B Antibody is affinity chromatography purified via peptide column.
|Homo sapiens family with sequence similarity 193, member B (FAM193B), transcript variant 1|
|DKFZp313I142; FLJ10404; KIAA1931|
|FAM193B Antibody: FAM193B, also known as IRIZIO, was initially identified as a protein that is upregulated in alveolar rhabdomyosarcoma (ARMS), a type of fast-growing tumor characterized by chromosomal translocations fusing the PAX3 or PAX7 gene with that of FOXO1. It has been suggested that, in addition to the PAX3-FOXO1 gene fusion, disruption of the Rb and p53 pathways is required for full ARMS tumorigenesis. In PAX3-FOXO1-expressing primary mouse fibroblasts that possessed a defective p53 pathway, FAM193B expression enabled the tumorigenic transformation, suggesting that FAM193B may contribute to rhabdomyosarcomagenesis in humans.|
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Western blot analysis of FAM193B in Jurkat cell lysate with FAM193B antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunofluorescence of FAM193B in Jurkat cells with FAM193B antibody at 20 ug/mL.