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Anti-FAIM3 Antibody EPR3811


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against TOSO / FAIM3(clone EPR3811)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401671) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human TOSO / FAIM3 was used as an immunogen.
Clone NameEPR3811 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; ICC: 1:50 - 1:100
Predicted MW Explanation 43 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens Fas apoptotic inhibitory molecule 3 (FAIM3), transcript variant 1
Alternative NameFCMR; TOSO
Database LinkNP_005440
Entrez Gene 9214 Human
Entrez Gene 69169 Mouse
Entrez Gene 548326 Rat
FunctionFas apoptotic inhibitory molecule 3 (FAIM3) / TOSO is a single-pass membrane protein that inhibits FAS-induced apoptosis, preventing CASP8 processing through CFLAR up-regulation. FAIM3 / TOSO protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. It seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. FAIM3 / TOSO is specifically expressed in lymph nodes, peripheral blood leukocytes, lung, thymus, and kidneys (1).
Related PathwayTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-FAIM3 antibody [EPR3811]; All lanes : Anti-FAIM3 antibody [EPR3811] at 1/1000 dilution.Lane 1 : Human spleen lysate.Lane 2 : Human fetal lung lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 43 kDa.Observed band size : 63 kDa .


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