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Home Antibody All anti-FAIM3 antibodies

Anti-FAIM3 Antibody EPR3811

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307218
  • Rabbit monoclonal antibody against TOSO / FAIM3(clone EPR3811)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401671) , 20ug
100ul $325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human TOSO / FAIM3 was used as an immunogen.
Clone NameEPR3811 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; ICC: 1:50 - 1:100
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens Fas apoptotic inhibitory molecule 3 (FAIM3), transcript variant 1
Alternative NameFCMR; TOSO
Database LinkNP_005440
FunctionFas apoptotic inhibitory molecule 3 (FAIM3) / TOSO is a single-pass membrane protein that inhibits FAS-induced apoptosis, preventing CASP8 processing through CFLAR up-regulation. FAIM3 / TOSO protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. It seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. FAIM3 / TOSO is specifically expressed in lymph nodes, peripheral blood leukocytes, lung, thymus, and kidneys (1).
Related Pathway

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WB Image
Western blot - Anti-FAIM3 antibody [EPR3811]; All lanes : Anti-FAIM3 antibody [EPR3811] at 1/1000 dilution.Lane 1 : Human spleen lysate.Lane 2 : Human fetal lung lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 43 kDa.Observed band size : 63 kDa .

 

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