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Home Antibody All anti-FAIM antibodies

Anti-FAIM Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306048
  • Rabbit Polyclonal FAIM Antibody
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenFAIM antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human FAIM .
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 5 - 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens Fas apoptotic inhibitory molecule (FAIM), transcript variant 1
Alternative NameFAIM1
Database LinkNP_001028202
Entrez Gene 55179 Human
Entrez Gene 23873 Mouse
FunctionThe susceptibility of primary splenic B cells to Fas-mediated apoptosis is regulated in a receptor-specific fashion. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic proteins Bcl-xL, FLIP, and a recently identified protein termed FAIM. This molecule is broadly expressed in various tissues and exists in at least three isoforms. It is thought that resistance to Fas killing via increased expression of FAIM protects foreign antigen-specific B cells during interactions with FasL-bearing T cells whereas autoreactive B cells are deleted via Fas-dependent cytotoxicity. More recent results have indicated that FAIM interacts with both Trk and p75 neurotrophin receptor and may play a role in promoting neurite outgrowth in different neuronal systems by a mechanism involving the activation of NF-kappaB and the Ras-ERK pathway.
Related Pathway

* Availability is in business days
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WB Image
Western blot analysis of FAIM in human spleen tissue lysate with FAIM antibody at (A) 5 and (B) 10 µg/ml.

 

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