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Home Antibody All anti-FADD antibodies
UltraMAB

Anti-FADD GAT Antibody Polyclonal

Generated by Genomic Immunization

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA590165 Rabbit Polyclonal FADD Antibody 100ug $325 In Stock
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WB(2)
IHC(5)
ELISA(1)

OriGene Data

ImmunogenDNA immunization. This antibody is specific for the Middle Region of the target protein.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman , Dog Concentration0.9mg/ml
Guaranteed Application *WB, ELISA, IHC Suggested Dilutions WB 1:5000~20000, IHC 1:150, ELISA 1:100-1:2000
Buffer20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
Purification The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
Note This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT

Reference Data

Target NameHomo sapiens Fas (TNFRSF6)-associated via death domain (FADD)
Alternative NameGIG3; MORT1
Database LinkNP_003815
Entrez Gene 8772 Human
Entrez Gene 611694 Dog
FunctionFas-associating protein with death domain (FADD) is an adaptor protein involved in the apoptosis induced by Fas and TNF-R1, and mitogen induced cell proliferation (1). FADD consists of death domain (DD) at the C-terminal and death effector domain (DED) at the N-terminal (2). DD interacts with Fas and TNF-R1, which exposes the DED portion on the FADD. Unmasked DED binds to the DED of pro-caspase-8, which activates the cysteine protease cascade (3). The development of autoimmune lymphoproliferative (lpr) diseases has been linked to inactivation of Fas-FADD interaction (4). Also, the deficiency in FADD can inhibit TRAIL-induced cell apoptosis.
Related PathwayDruggable Genome ApoptosisToll-like receptor signaling pathwayRIG-I-like receptor signaling pathwayAlzheimer's diseasePathways in cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FADD (RC201805, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FADD.
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Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-FADD polyclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
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ELISA: FADD Antibody
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-FADD Rabbit Polyclonal antibody. (TA590165)
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Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-FADD Rabbit Polyclonal antibody. (TA590165)
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Immunohistochemical staining of paraffin-embedded Human prostate tissue using anti-FADD Rabbit Polyclonal antibody. (TA590165)
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Immunohistochemical staining of paraffin-embedded Human lymph node tissue using anti-FADD Rabbit Polyclonal antibody. (TA590165)
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Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-FADD Rabbit Polyclonal antibody. (TA590165)
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