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Home Antibody All anti-FADD antibodies

Anti-FADD Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA321603
  • Anti-FADD Rabbit Polyclonal Antibody
100ul 325 In Stock
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IHC(2)
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Also for FADD (NM_003824)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length fusion protein
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1.5mg/ml
Guaranteed Application *IHC Suggested DilutionsELISA: 1:1000-5000, IHC: 1:50-150
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens Fas (TNFRSF6)-associated via death domain (FADD)
Alternative NameGIG3; MORT1
Database LinkNP_003815
Entrez Gene 8772 Human
Entrez Gene 14082 Mouse
Entrez Gene 266610 Rat
FunctionThe protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain; this protein can be recruited by TNFRSF6/Fas-receptor; tumor necrosis factor receptor; TNFRSF25; and TNFSF10/TRAIL-receptor; and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein; which allows it to recruit caspase-8; and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Related PathwayDruggable Genome ApoptosisToll-like receptor signaling pathwayRIG-I-like receptor signaling pathwayAlzheimer's diseasePathways in cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

IHC Image
Predicted cell location: Cytoplasm. Positive control: Human thyroid and esophagus cancer tissue. Recommended dilution: 1/50-150 The image on the left is immunohistochemistry of paraffin-embedded Human thyroid and esophagus cancer tissue using FADD antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification: x200)
IHC Image
Predicted cell location: Cytoplasm. Positive control: Human thyroid and esophagus cancer tissue. Recommended dilution: 1/50-150 The image on the left is immunohistochemistry of paraffin-embedded Human thyroid and esophagus cancer tissue using FADD antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification: x200)

 

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