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Home Antibody All anti-FADD antibodies

Anti-FADD Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA321603
  • Anti-FADD Rabbit Polyclonal Antibody
100ul 325 In Stock
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IHC(2)
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Also for FADD (NM_003824)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length fusion protein
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1.5mg/ml
Guaranteed Application *IHC Suggested DilutionsELISA: 1:1000-5000, IHC: 1:50-150
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens Fas (TNFRSF6)-associated via death domain (FADD)
Alternative NameGIG3; MORT1
Database LinkNP_003815
FunctionThe protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain; this protein can be recruited by TNFRSF6/Fas-receptor; tumor necrosis factor receptor; TNFRSF25; and TNFSF10/TRAIL-receptor; and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein; which allows it to recruit caspase-8; and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Related Pathway
Apoptosis
Toll-like receptor signaling pathway

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IHC Image
Predicted cell location: Cytoplasm. Positive control: Human thyroid and esophagus cancer tissue. Recommended dilution: 1/50-150 The image on the left is immunohistochemistry of paraffin-embedded Human thyroid and esophagus cancer tissue using FADD antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification: x200)
IHC Image
Predicted cell location: Cytoplasm. Positive control: Human thyroid and esophagus cancer tissue. Recommended dilution: 1/50-150 The image on the left is immunohistochemistry of paraffin-embedded Human thyroid and esophagus cancer tissue using FADD antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification: x200)

 

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