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Anti-FADD Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA321602 Anti-FADD Rabbit Polyclonal Antibody 100ul 325
2-3 Weeks
LC401265 FADD HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenFull length fusion protein
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1.1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsELISA: 1:2000-10000, WB: 1:1000-5000, IHC: 1:50-100
Predicted MW Explanation 23kDa
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens Fas (TNFRSF6)-associated via death domain (FADD)
Alternative NameGIG3; MORT1
Database LinkNP_003815
Entrez Gene 8772 Human
Entrez Gene 14082 Mouse
Entrez Gene 266610 Rat
FunctionThe protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain; this protein can be recruited by TNFRSF6/Fas-receptor; tumor necrosis factor receptor; TNFRSF25; and TNFSF10/TRAIL-receptor; and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein; which allows it to recruit caspase-8; and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Related PathwayDruggable Genome ApoptosisToll-like receptor signaling pathwayRIG-I-like receptor signaling pathwayAlzheimer's diseasePathways in cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Predicted band size: 23 kDa . Positive control: Mouse spleen tissue and RAW264.7 cell lysate. Recommended dilution: 1/1000-5000. (Gel: 8%+12%SDS-PAGE Lane1: Mouse spleen tissue lysate Lane2: Mouse RAW264.7 cell lysate Lysates: 30 ug per lane Primary antibody: 1/550 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 5 seconds)

IHC Image
Predicted cell location: Cytoplasm. Positive control: Human colorectal cancer tissue. Recommended dilution: 1/50-100 The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using FADD antibody at dilution 1/35, on the right is treated with the fusion protein. (Original magnification: x200)


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