Fas-associating protein with death domain (FADD) is an adaptor protein involved in apoptosis induced by Fas, TNF-R1, and mitogen induced cell proliferation (1). FADD consists of a death domain (DD) at the C-terminal and death effector domain (DED) at the N-terminal (2). DD interacts with Fas and TNF-R1, which exposes the DED portion on the FADD. Unmasked DED binds to the DED of pro-caspase-8, which activates the cysteine protease cascade (3). The development of autoimmune lymphoproliferative (lpr) diseases has been linked to the inactivation of Fas-FADD interaction (4). In addition, a deficiency in FADD can inhibit TRAIL-induced cell apoptosis.
Toll-like receptor signaling pathway
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