The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq].
Related Pathway
Apoptosis
Toll-like receptor signaling pathway
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Western blot analysis on Jurkat cell lysates using anti-phosho FADD (pS194) RabMAb (TA303863), 1:500 dilution. Cells were either (A) untreated (B) treated with calyculin A
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