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Anti-FADD PHOSPHO Antibody EPR1816Y
Also for FADD (NM_003824)
|A synthetic peptide corresponding to residues surrounding serine 194 of human FADD was used as immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:500; IP: 1:30
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens Fas (TNFRSF6)-associated via death domain (FADD)|
|The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq]. |
Toll-like receptor signaling pathway
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Western blot - FADD (phospho S194) antibody [EPR1816Y]; All lanes : Anti-FADD (phospho S194) antibody [EPR1816Y] at 1/500 dilution.Lane 1 : Jurkat cell lysate, untreated.Lane 2 : Jurkat cell lysate, treated with calyculin A.Lysates/proteins at 10 µg per lane.Secondary.HRP conjugated Goat anti-Rabbit at 1/2000 dilution.Predicted band size : 23 kDa.Observed band size : 27 kDa .