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Home Antibody All anti-Ebi3 antibodies

Anti-Ebi3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319482
  • Rabbit polyclonal EBI-3 antibody Peroxidase Conjugated
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenAnti-EBI-3 / IL27 beta Antibody Peroxidase Conjugate was prepared by repeated immunizations with recombinant mouse EBI3.
Clone Name IsotypeIgG
Species ReactivityMouse, rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsELISA: 1:20,000 - 1:100,000, WB: 1:2,000 - 1:10,000, IHC: 1:1,000 - 1:5,000
Buffer0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Note The cytokine Interleukin 27 (IL-27) is produced in response to inflammation. It is made by activated antigen presenting cells including monocytes, endothelial cells, and dendritic cells. IL-27 consists of a heterodimeric combination of Epstein-Barr virus-induced molecule 3 (EBI3, or IL-27B) non-covalently linked with IL-27 p28 (or IL-27A). It is a regulator of T helper cell development and suppressor of T-cell proliferation. IL-27 has both pro- and anti-inflammatory properties. It can stimulate cytotoxic T cell activity and induce isotype switching in B-cells. It has diverse effects on innate immune cells. It induces monocytes and mast cells to secrete pro-inflammatory cytokines. When infection is present, IL-27 induces naive CD4+ T cells to proliferate and develop Th1 cell responses. As an anti-inflammatory regulator, IL-27 can inhibit Th1 or Th2 responses and restrict the strength and duration of adaptive immune responses. The IL-27 p28 subunit, a 28 kDa glycoprotein belonging to the type I cytokine family, is homologous to IL-12 p35, IL-23 p19, and IL-6. The EBI3 (Epstein-Barr virus-induced molecule 3, or IL-27B) subunit is a 34 kDa glycoprotein containing two fibronectin type III domains, and belongs to the type I cytokine receptor family. It can exist as a homodimer and can also heterodimerize with IL-12 p35. It is homologous to the p40 subunit of IL-12 and IL-23 and to the extracellular domain of IL-6 R. EBI3 can heterodimerize also with IL-12 p35, or can exist as a homodimer.

Reference Data

Target NameMus musculus Epstein-Barr virus induced gene 3 (Ebi3)
Alternative NameEBI-3; IL-27
Database LinkNP_056581
Function
Related Pathway

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WB Image
The expected band is a non-glycosylated polypeptide chain consisting of 207 amino acids and is approximately 23 kDa in size corresponding to the mature mouse EBI3 protein by western blotting in appropriate cell lysate or extract.

 

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