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Home Antibody All anti-EZR antibodies

Anti-EZR Antibody EPR803

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307863
  • Rabbit monoclonal antibody against Ezrin(clone EPR803)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401164) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(2)
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Also for EZR (NM_003379)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Ezrin was used as an immunogen.
Clone NameEPR803 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:10000 - 1:50000; IHC-P: 1:250 - 1:500
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC/IF or IP.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,ICC/IF or IP.

Reference Data

Target NameHomo sapiens ezrin (EZR), transcript variant 1
Alternative NameCVIL; CVL; HEL-S-105; VIL2
Database LinkNP_003370
Entrez Gene 7430 Human
FunctionEzrin, a member of the Ezrin, Radixin, Moesin (ERM) family, is a linker protein located between cell surface receptors, adhesion molecules, and actin cytoskeleton (1-2). Ezrin activity is regulated by intramolecular interactions between N- and C-terminal ERM association domains (3). Ezrin tyrosine phosphorylation can also be induced by EGF, PDGF and HGF stimulation. Ezrin interacts with PI3-K protein kinase A and Rho (4). In response to epidermal growth factor (EGF) the microvillar core protein ezrin is phosphorylated transiently to a high level on tyrosine residues in human epidermoid carcinoma A431 cells. Tyr145, lies in the N-terminal region of homology that is common to the band 4.1-talin-ezrin protein family. This tyrosine residue and its vicinal amino acids are conserved throughout the family members, including radixin, moesin, and the two phosphotyrosine phosphatases, PTP H1 and PTP MEG, but not in band 4.1 or talin (5).
Related PathwayDruggable Genome Leukocyte transendothelial migrationRegulation of actin cytoskeletonPathogenic Escherichia coli infection

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Ezrin antibody [EPR803]; All lanes : Anti-Ezrin antibody [EPR803] at 1/10000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : 293Y cell lysate.Lane 3 : A549 cell lysate.Lane 4 : SH-SY5Y cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat Anti-rabbit HRP at 1/2000 dilution.Predicted band size : 69 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ezrin antibody [EPR803]; Immunohistochemical analysis of paraffin-embedded Human kidney tissue labelling Ezrin with TA307863 at 1/250 dilution.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ezrin antibody [EPR803]; Immunohistochemical analysis of paraffin-embedded Human transitional cell carcinoma tissue labelling Ezrin with TA307863 at 1/250 dilution.

 

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