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Anti-EXOSC7 Antibody EPR7452
Also for EXOSC7 (NM_015004)
|A synthetic peptide corresponding to residues in human EXOSC7 was used as an immunogen.|
||Tissue culture supernatant
||Lot dependent; please refer to CoA along with shipment
|WB, ASSAY, IHC
||WB: 1:10000 - 1:50000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt or ICC.|
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Is unsuitable for Flow Cyt or ICC.
|Homo sapiens exosome component 7 (EXOSC7), transcript variant 1|
|EAP1; hRrp42p; p8; RRP42; Rrp42p|
|EXOSC7 is a non-catalytic component of the RNA exosome complex, which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as anti-sense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome is reported to be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs (1).|
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Western blot - Anti-EXOSC7 antibody [EPR7452]; All lanes : Anti-EXOSC7 antibody [EPR7452] at 1/10000 dilution.Lane 1 : K562 cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : NCI-H460 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 32 kDa.
Other-Anti-EXOSC7 antibody [EPR7452](TA310471); Equilibrium disassociation constant (KD)..
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EXOSC7 antibody [EPR7452]; TA310471, at 1/100 dilution, staining EXOSC7 in paraffin-embedded Human colon tissue by Immunohistochemistry.