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Home Antibody All anti-ETV4 antibodies
UltraMAB

Anti-ETV4 GAT Antibody Polyclonal

Generated by Genomic Immunization

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA590716
  • Rabbit Polyclonal Pea3 Antibody
100ug 325 In Stock
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WB(1)

OriGene Data

ImmunogenDNA immunization. This antibody was made against a protein fragment from the N Terminus Region (NM_001986).
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman Concentration0.7mg/ml
Guaranteed Application *WB Suggested Dilutions WB 1:20000,ELISA 1:100-1:2000
Buffer20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
Purification The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
Note This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT This antibody is not recommended for IHC.

Reference Data

Target NameHomo sapiens ets variant 4 (ETV4), transcript variant 1
Alternative NameE1A-F; E1AF; PEA3; PEAS3
Database LinkNP_001977
FunctionETV4: ets variant gene 4 (E1A enhancer binding protein, E1AF). Several members of the Ets gene family are known to encode sequence specific DNA binding proteins. These include mouse PU.1, mouse and human Ets-1, Drosophila E74, chicken and human Ets-2 and rat GABP-alpha. Each of these proteins recognizes similar motifs in DNA that share a centrally located 5'-GGAA-3' element. For instance, PEA3 binds the motif 5'-AGGAAG-3' (the PEA-3 motif), but does not bind to the sequence 5'-AGGAAC-3', recognized by PU.1, although PU.1 binds equally well to both sequences. It appears that all of the Ets proteins recognize the same central core sequence but that each protein interacts with unique sequences that flank this core. PEA3 is expressed at readily detectable levels in cells of epithelial and fibroblastic origin but is not expressed in hematopoietic cells. This is in contrast to other members of the Ets gene family, such as Ets-1, Ets-2 and Fli-1, each of which is expressed primarily in cells of hematopoietic origin.
Related Pathway

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WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ETV4 (RC215093, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ETV4.

 

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