Home Antibody All anti-ESX1 antibodies
Also for ESX1 (NM_153448)
|ESX1 antibody was raised against a 19 amino acid peptide near the center of human ESX1.|
|WB, IHC, IF
||WB: 1 - 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens ESX homeobox 1 (ESX1)|
Entrez Gene 80712 Human
|Homeobox proteins are transcription factors that contain a helix-turn-helix DNA binding domain termed the homeodomain. ESX1 is an X-linked homeobox gene primarily expressed in the placenta and testis and contains two functional domains: the homeodomain and the proline-rich domain. During embryogenesis, ESX1 is expressed in the extraembryonic tissues, including the endoderm of the visceral yolk sac, the ectoderm of the chorion and the labyrinthine trophoblast of the chorioallantoic placenta. ESX1 can act like a transcriptional repressor to the human oncogene K-ras and treatment of human cancer cells with an ESX1 protein fragment containing the homeodomain reduces the tumorgenicity of cells containing oncogenic K-ras mutations, suggesting ESX1 may be useful as a therapeutic treatment for these cancers.|
|Transcription Factors |
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Western blot analysis of ESX1 in human testis tissue lysate with ESX1 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of ESX1 in human testis tissue with ESX1 antibody at 2.5 ug/mL.
Immunofluorescence of ESX1 in human testis tissue with ESX1 antibody at 20 ug/mL.