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Anti-ESRRG Antibody EPR8100
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for ESRRG (NM_001134285)
|A synthetic peptide corresponding to residues in human Estrogen-related receptor gamma was used as an immunogen.|
|Human, Mouse, Rat
||WB: 1:10,000 - 50,000; IHC 1:250 - 500; ICC: 1:250 - 500; FC: 1:100 - 500;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens estrogen-related receptor gamma (ESRRG), transcript variant 4|
|ERR3; ERRgamma; NR3B3|
|Estrogen-related receptor gamma is a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element. The ESRR family is closely related to the estrogen receptor (ER) family. They share target proteins, co-regulators and promoters, and by targeting the same set of proteins, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that Estrogen-related receptor gamma functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation (1). |
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Western blot analysis on (A) human ovary cancer, (B) human breast, (C) fetal heart, and (D) human spleen lysates using anti-Estrogen-related receptor gamma RabMAb.