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Home Antibody All anti-ESRRG antibodies

Anti-ESRRG Antibody EPR8100

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310470
  • Rabbit Monoclonal antibody against Estrogen-related receptor gamma (ESRRG)
100ul 325 3-7 Days
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WB(1)
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Also for ESRRG (NM_001134285)
cDNA Clone shRNA/siRNA Primer Pair Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Estrogen-related receptor gamma was used as an immunogen.
Clone NameEPR8100 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
Predicted MW Explanation 51 kDa
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for IHC-P or IP.

Reference Data

Target NameHomo sapiens estrogen-related receptor gamma (ESRRG), transcript variant 4
Alternative NameERR3; ERRgamma; NR3B3
Database LinkNP_001127757
Entrez Gene 2104 Human
Entrez Gene 26381 Mouse
Entrez Gene 360896 Rat
FunctionEstrogen-related receptor gamma is a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element. The ESRR family is closely related to the estrogen receptor (ER) family. They share target proteins, co-regulators and promoters, and by targeting the same set of proteins, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that Estrogen-related receptor gamma functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation (1).
Related PathwayNuclear Hormone ReceptorTranscription FactorsDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Estrogen Related Receptor gamma antibody [EPR8100]; All lanes : Anti-Estrogen Related Receptor gamma antibody [EPR8100] at 1/1000 dilution.Lane 1 : Human ovary cancer lysate.Lane 2 : Human breast lysate.Lane 3 : Human fetal heart lysate.Lane 4 : Human spleen lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 51 kDa.

 

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