Anti-ESRRG Antibody, EPR8100

Also for ESRRG (NM_001134285)

OriGene Data

Immunogen	A synthetic peptide corresponding to residues in human Estrogen-related receptor gamma was used as an immunogen.
Clone Name	EPR8100	Isotype
Species Reactivity	Human, Mouse, Rat	Concentration
Guaranteed Application *	WB	Suggested Dilutions	WB: 1:10,000 - 50,000; IHC 1:250 - 500; ICC: 1:250 - 500; FC: 1:100 - 500;
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens estrogen-related receptor gamma (ESRRG), transcript variant 4
Alternative Name	ERR3; ERRgamma; NR3B3
Database Link	NP_001127757
Function	Estrogen-related receptor gamma is a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element. The ESRR family is closely related to the estrogen receptor (ER) family. They share target proteins, co-regulators and promoters, and by targeting the same set of proteins, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that Estrogen-related receptor gamma functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation (1).
Related Pathway

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WB Image

Western blot analysis on (A) human ovary cancer, (B) human breast, (C) fetal heart, and (D) human spleen lysates using anti-Estrogen-related receptor gamma RabMAb.

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

HRP
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PE
FITC
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DyLight® 594
DyLight® 633

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Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Anti-ESRRG Antibody EPR8100

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data