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Anti-ESR1 Antibody E91


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal Antibody against ESR1 (Clone E91)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400046) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Ser118 of human ERalpha was used as immunogen. The antibody only detects ERalpha phosphorylated on Serine 118.
Clone NameE91 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1: 1,000; IHC: 1:50; ICC: 1:50-1: 100
Predicted MW Explanation 66 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens estrogen receptor 1 (ESR1), transcript variant 1
Alternative NameER; Era; ESR; ESRA; ESTRR; NR3A1
Database LinkNP_000116
Entrez Gene 2099 Human
FunctionEstrogen receptor alpha (ER alpha) is a nuclear protein and member of the steroid hormone receptor family. ER alpha possesses both DNA binding and ligand binding domains, and exerts a significant role in activating the transcription of certain genes (1). Ligand-dependent dimerization and phosphorylation on serines, 104, 106, and 118 function to regulate the transcriptional activation of ER alpha (2). The phosphorylation of the human estrogen receptor (ER) serine residue at position 118 is required for full activity of the ER activation function 1 (AF-1) (3).
Related PathwayNuclear Hormone ReceptorTranscription FactorsDruggable Genome

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WB Image
Western blot - Estrogen Receptor alpha (phospho S118) antibody [E91]; All lanes : Anti-Estrogen Receptor alpha (phospho S118) antibody [E91] at 1/1000 dilution.Lane 1 : MCF7 cell lysate (untreated).Lane 2 : MCF7 cell lysate (treated with b-Estradiol and EGF).Predicted band size : 66 kDa.Observed band size : 60 kDa .
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - Estrogen Receptor alpha (phospho S118) antibody [E91]; Immunohistochemical staining of (A) untreated and (B) Phosphatase-treated paraffin-embedded human breast adenocarcinoma using TA300369 at 1:50 dilution.
IF Image
Immunofluorescence - Estrogen Receptor alpha (phospho S118) antibody [E91]; Immunofluorescent staining of (A) untreated and (B) Phosphatase-treated MCF-7 cells using TA300369.


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