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Anti-ERG Antibody

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA323882 Anti-ERG rabbit polyclonal antibody 100ul $325 In Stock
LC427827 ERG HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenFusion protein corresponding to a region derived from 1-150 amino acids of human v-ets erythroblastosis virus E26 oncogene homolog (avian)
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1.3mg/ml
Guaranteed Application * Suggested DilutionsELISA: 1:2000-5000, WB: 1:500-2000, IHC: 1:50-200
Predicted MW Explanation 54kDa
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog (ERG), transcript variant 3
Alternative Nameerg-3; p55
Database LinkNP_001129626
Entrez Gene 2078 Human
Entrez Gene 13876 Mouse
Entrez Gene 170909 Rat
FunctionThis gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Related PathwayTranscription FactorsDruggable Genome

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