Excision Repair Cross Complementing 1 (ERCC1) is a mammalian nucleotide excision repair (NER) enzyme involved in repair of damaged DNA. ERCC1 is a homologous to RAD10 in Saccharomyces cerevisiae which is required in mitotic intrachromosomal recombination and repair. Specifically, during DNA repair, ERCC1 forms a complex with XPF/ERCC4 which makes incision 5’ to the lesion site (1). ERCC1 is required in repair of cisplatin-induced DNA adducts and ultraviolet (UV)-induced DNA damage. A defect in ERCC1 can lead to Cerebro-oculo-facio-skeletal syndrome type 4 (COFS4) and UV-induced skin cancer (2).
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