Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) (ERCC1), transcript variant 1
Synonyms:
COFS4; RAD10; UV20
Immunogen
A synthetic peptide corresponding to N-terminus of human ERCC1 was used. Might also detect heterodimer composed of ERCC1 and XPF/ERCC4 at 100 -150 kDa.
Buffer
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Excision Repair Cross Complementing 1 (ERCC1) is a mammalian nucleotide excision repair (NER) enzyme involved in repair of damaged DNA. ERCC1 is a homologous to RAD10 in Saccharomyces cerevisiae which is required in mitotic intrachromosomal recombination and repair. Specifically, during DNA repair, ERCC1 forms a complex with XPF/ERCC4 which makes incision 5’ to the lesion site (1). ERCC1 is required in repair of cisplatin-induced DNA adducts and ultraviolet (UV)-induced DNA damage. A defect in ERCC1 can lead to Cerebro-oculo-facio-skeletal syndrome type 4 (COFS4) and UV-induced skin cancer (2).
Related Pathway
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
