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Anti-ERBB4 PHOSPHO Antibody EPR2273(2)


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against HER4/ErbB4 Phospho (pY1284)(clone EPR2273(2)) (Phospho-Specific)
100ul $325 3 Weeks
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Also for ERBB4 (NM_005235)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Tyrosine 1284 of human HER4/ErbB4 was used as an immunogen. This antibody only detects HER4/ErbB4 phosphorylated at HER4/ErbB4.
Clone NameEPR2273(2) IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF, FC Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
Predicted MW Explanation 147 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for IHC-P or IP.

Reference Data

Target NameHomo sapiens erb-b2 receptor tyrosine kinase 4 (ERBB4), transcript variant JM-a/CVT-1
Alternative NameALS19; HER4; p180erbB4
Database LinkNP_005226
Entrez Gene 2066 Human
Entrez Gene 13869 Mouse
Entrez Gene 59323 Rat
FunctionHER4/ErbB4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. ErbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). ErbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The HER4/ErbB4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif, known as the PDZ domain (3).
Related PathwayProtein KinaseTransmembraneDruggable Genome ErbB signaling pathwayCalcium signaling pathwayEndocytosis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - ErbB 4 (phospho Y1284) antibody [EPR2273(2)]; All lanes : Anti-ErbB 4 (phospho Y1284) [EPR2273(2)] antibody at 1/1000 dilution.Lane 1 : A431 cell lysate, untreated.Lane 2 : A431 cell lysate, treated with Epidermal Growth Factor (EGF) .Lysates/proteins at 10 ug/ml per lane.Predicted band size : 147 kDa.
Immunocytochemistry/ Immunofluorescence - ErbB 4 (phospho Y1284) antibody [EPR2273(2)]; Immunofluorescent staining of A431 cells using TA307616 at a dilution of 1/100.
Flow Cytometry - ErbB 4 (phospho Y1284) antibody [EPR2273(2)]; TA307616 at 1/10 dilution staining ErbB 4 in HeLa cells by Flow cytometry. .Green: Permeabilized A431 cells, untreated .Red: Permeabilized A431 cells, treated with EGF. .Blue: Permeabilized A431 cells, treated with EGF and preincubated with phospho-ErbB 4 (pY1284) peptide .Orange: Permeabilized A431 cells, treated with EGF and preincubated with non-phospho-ErbB 4(pY1284) peptide.


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