HER4/ErbB4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. ErbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). ErbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The HER4/ErbB4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif, known as the PDZ domain (3).
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
Flow cytometric analysis of permeabilized A431 cells, untreated (green) or EGF-treated (red) using anti-HER4/ErbB4 Phospho (pY1284) RabMAb, and EGF-treated A431 cells using the same antibody preincubated with phospho-HER4/ErbB4 Phospho (pY1284) peptide (blue) or non-phospho-HER4/ErbB4 Phospho (pY1284) peptide (orange)
Researchers who bought this antibody have also purchased: