Home Antibody All anti-ERBB4 antibodies
Anti-ERBB4 PHOSPHO Antibody EP2272AY
Also for ERBB4 (NM_005235)
|A phospho specific peptide corresponding to residues surrounding tyrosine 1258 of human Her4/ErbB-4 was used as an immunogen. This antibody detects Her4/ErbB-4 phosphorylated on tyrosine 1258.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:5000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 (ERBB4), transcript variant JM-a/CVT-1|
|ALS19; HER4; p180erbB4|
Entrez Gene 2066 Human
Entrez Gene 13869 Mouse
Entrez Gene 59323 Rat
|This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq]. |
|Protein KinaseTransmembraneDruggable Genome ErbB signaling pathwayCalcium signaling pathwayEndocytosis|
* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
Western blot - ErbB 4 (phospho Y1258) antibody [EP2272AY]; All lanes : Anti-ErbB 4 (phospho Y1258) antibody [EP2272AY] at 1/2000 dilution.Lane 1 : SKBR3 cell lysates treated with EGF.Lane 2 : SKBR3 cell lysates untreated.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 147 kDa.Observed band size : 180 kDa .