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Home Antibody All anti-ERBB4 antibodies

Anti-ERBB4 PHOSPHO Antibody EP2272AY

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SKU Description Amount Price Availability*  
TA303505
  • Rabbit monoclonal antibody against Her4 / ErbB-4 Phospho (pY1258) (EP2272AY ) (phospho-specific)
100ul 325 In Stock
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OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding tyrosine 1258 of human Her4/ErbB-4 was used as an immunogen. This antibody detects Her4/ErbB-4 phosphorylated on tyrosine 1258.
Clone NameEP2272AY IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:5000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 (ERBB4), transcript variant JM-a/CVT-1
Alternative NameALS19; HER4; p180erbB4
Database LinkNP_005226
FunctionThis gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq].
Related Pathway

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WB Image
Western blot - ErbB 4 (phospho Y1258) antibody [EP2272AY]; All lanes : Anti-ErbB 4 (phospho Y1258) antibody [EP2272AY] at 1/2000 dilution.Lane 1 : SKBR3 cell lysates treated with EGF.Lane 2 : SKBR3 cell lysates untreated.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 147 kDa.Observed band size : 180 kDa .

 

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