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Home Antibody All anti-ERBB3 antibodies

Anti-ERBB3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA323486
  • Anti-ERBB3 Rabbit Polyclonal Antibody
100ul 325 2-3 Weeks
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IHC(1)
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Also for ERBB3 (NM_001982)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFusion protein corresponding to C terminal 250 amino acids of human v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1.1mg/ml
Guaranteed Application *IHC Suggested DilutionsELISA: 1:1000-5000, IHC: 1:50-150
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (ERBB3), transcript variant 1
Alternative Namec-erbB-3; c-erbB3; ErbB-3; erbB3-S; HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3
Database LinkNP_001973
Entrez Gene 2065 Human
Entrez Gene 13867 Mouse
Entrez Gene 29496 Rat
FunctionThis gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However; it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers; including prostate; bladder; and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported; but they have not been thoroughly characterized.
Related PathwayProtein KinaseSecreted ProteinTransmembraneStem cell - PluripotencyAdult stem cellsDruggable Genome ErbB signaling pathwayCalcium signaling pathwayEndocytosis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

IHC Image
Predicted cell location: Cytoplasm, Cell membrane. Positive control: Human colon cancer tissue. Recommended dilution: 1/50-150 The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using ERBB3 antibody at dilution 1/35, on the right is treated with the fusion protein. (Original magnification: x200)

 

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