A PKG inhibitor increases Ca2+-regulated exocytosis in guinea pig antral mucous cells: cAMP accumulation via PDE2A inhibition Am J Physiol Gastrointest Liver Physiol, May 2013; 304: G773 - G780.
[PDE2A]
Lck tyrosine kinase mediates ß1-integrin signalling to regulate Schwann cell migration and myelination Nature Communications 4, 1912 doi:10.1038/ncomms2928
[OCT6]
Notch1-Hes1 signalling axis in the tumourigenesis of biliary neuroendocrine tumours J. Clin. Pathol., May 2013; 66: 386 - 391.
[Notch 1]
Selenoprotein K is required for palmitoylation of CD36 in macrophages: implications in foam cell formation and atherogenesis J. Leukoc. Biol., May 2013; 93: 771 - 780.
[anti-DDK]
UltraMAB™ Antibodies - Validated with 10K Protein Chip
Western blot analysis of cell lysates of HEK293 transfected with ERBB2 cDNA (Left lane) or untransfected (Right lane) by using ERBB2 UltraMAB (UM500036, clone UMAB36, 1:2000).
Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-ERBB2 monoclonal antibody (Clone UMAB36) at 1:500.
Immunohistochemical staining of paraffin-embedded Carcinoma of bladder tissue using anti-ERBB2mouse monoclonal antibody. (Clone UMAB36, Dilution 1:100)
Immunohistochemical staining of paraffin-embedded Carcinoma of breast tissue (HER2+++) using anti-ERBB2mouse monoclonal antibody. (Clone UMAB36, Dilution 1:100)
OriGene overexpression protein microarray chip was immunostained with UltraMAB anti-ERBB2 mouse monoclonal antibody (Clone UMAB36). The positive reactive proteins are highlighted with two red arrows in the enlarged subarray. All the positive controls spotted in this subarray are also labeled for clarification. These data show that UltraMAB anti-ERBB2 (Clone UMAB36) very specifically recognizes ERBB2 antigen on OriGene protein microarray chip.
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].
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Western blot analysis of cell lysates of HEK293 transfected with ERBB2 cDNA (Left lane) or untransfected (Right lane) by using ERBB2 UltraMAB (UM500036, clone UMAB36, 1:2000).
Immunohistochemical staining of paraffin-embedded Carcinoma of breast tissue (HER2+++) using anti-ERBB2mouse monoclonal antibody. (Clone UMAB36, Dilution 1:100)
OriGene overexpression protein microarray chip was immunostained with UltraMAB anti-ERBB2 mouse monoclonal antibody (Clone UMAB36). The positive reactive proteins are highlighted with two red arrows in the enlarged subarray. All the positive controls spotted in this subarray are also labeled for clarification. These data show that UltraMAB anti-ERBB2 (Clone UMAB36) very specifically recognizes ERBB2 antigen on OriGene protein microarray chip.
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