Home Antibody All anti-ERBB2 antibodies
Also for ERBB2 (NM_001005862)
|erbB-2 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human erbB-2.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant 2|
|CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1|
Entrez Gene 2064 Human
Entrez Gene 13866 Mouse
Entrez Gene 24337 Rat
|The ErbB family consists of four closely related tyrosine kinase receptors that act as potent mediators of normal cell growth and development. Aberrant expression or function of one or more of these receptors can play a major role in the development and evolution of cancer. ErbB-2, also known as HER2, has been implicated in the evolution of both breast and gastric cancers, and is evident in other cancer types such as ovarian and salivary gland tumors. ErbB-2 possesses an active tyrosine kinase domain, but no direct ligand has been identified yet. ErbB-2 is the preferred binding partner to the other members of the ErbB family and is thought to act primarily through the Ras-MAPK, PI3k-PKB/Akt, and PLC-PKC signaling pathways. Numerous anti-cancer strategies have been employed against erbB-2, such as antibody-based therapies to prevent ligand binding or receptor activation through dimerization, antibody-dependent cell mediated cytotoxicity, in addition to direct kinase inhibition to prevent molecular activation/downstream signaling.|
|Protein KinaseTransmembraneDruggable Genome ErbB signaling pathwayCalcium signaling pathwayFocal adhesionAdherens junctionPathways in cancerPancreatic cancerMore Pathways >> |
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Western blot analysis of erbB-2 in rat liver tissue lysate with erbB-2 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of erbB-2 in human liver tissue with erbB-2 antibody at 2.5 ug/ml.