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Home Antibody All anti-EPS15L1 antibodies

Anti-EPS15L1 Antibody EP1145Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300766
  • Rabbit Monoclonal Antibody against EPS15L1 (Clone EP1145Y)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC402859) , 20ug
100ul $325 In Stock
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WB(1)
IHC(1)
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Also for EPS15L1 (NM_021235)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human EPS15R was used as an immunogen.
Clone NameEP1145Y IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:50000; IP: 1:70; ICC: 1:50 - 1:100; FC: 1:10; IHC-P: Use at an assay dependent dilution
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens epidermal growth factor receptor pathway substrate 15-like 1 (EPS15L1), transcript variant 2
Alternative NameEPS15R
Database LinkNP_067058
FunctionEPS15 and EPS15R are substrates of the epidermal growth factor (EGF) receptor kinase that are characterized by the presence of a protein:protein interaction domain, the EH domain, and by their ability to bind to the clathrin adaptor protein complex adaptor protein 2. Evidence suggests that eps15 and eps15R are involved in endocytosis (1). The most striking difference between these two related proteins is that Eps15R is also found in the nucleus, whereas Eps15 is excluded from this compartment at steady state (2). Eps15R plays a key role in clathrin-mediated endocytosis of transmembrane receptors. Using a mutational approach, it has been found that the second ubiquitin-interacting motif (UIM) of Eps15 and Eps15R is essential for their ubiquitination (3).
Related Pathway
EGFR1 Signaling Pathway

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WB Image
Western blot - EPS15R antibody [EP1145Y]; Anti-EPS15R antibody [EP1145Y] at 1/50000 dilution + HeLa cell lysate at 10 µg.Secondary.goat anti-rabbit HRP labelled at 1/2000 dilution.Predicted band size : 94 kDa.Observed band size : 125 kDa .
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - EPS15R antibody [EP1145Y]; TA300766, at a 1/50 dilution, staining Human EPS15R in Breast Carcinoma, using Immunohistochemsitry, Paraffin embedded tissue.

 

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