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Anti-EPAS1 Antibody ep190b


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SKU Description Amount Price Availability*  
TA301435 Mouse Monoclonal Antibody against HIF-2 alpha (ep190b) 100ul $325 3 Weeks
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OriGene Data

ImmunogenHuman HIF-2 alpha amino acids 535-631.
Clone Nameep190b IsotypeIgG1
Species Reactivityhuman, rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500, IHC: 1: 150-1:300
BufferPBS and 0.1% sodium azide
Purification protein G purified

Reference Data

Target NameHomo sapiens endothelial PAS domain protein 1 (EPAS1)
Alternative NamebHLHe73; ECYT4; HIF2A; HLF; MOP2; PASD2
Database LinkNP_001421
Entrez Gene 2034 Human
Entrez Gene 29452 Rat
FunctionHypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-2 alpha is predominantly expressed in highly vascularized tissues of adult humans and endothelial cells of the embryonic and adult mouse, whereas HIF-1 alpha functions primarily in extravascular tissues. HIF-2 alpha is also a potent activator of the tie-2 gene, which is known to be selectively expressed in endothelial cells.
Related PathwayTranscription FactorsDruggable Genome Pathways in cancerRenal cell carcinoma

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HIF-2 alpha detected in hypoxic human lysate. Lane 1: normoxic A549 lysate control, lane 2: hypoxic A549 lysate
Staining of heart, cardiac myocytes


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